The daughter of a prominent samurai, Mariko has long known her place--she may be an accomplished alchemist, whose cunning rivals that of her brother Kenshin, but because she is not a boy, her future has always been out of her hands. At just seventeen years old, Mariko is promised to Minamoto Raiden, the son of the emperor's favorite consort--a political marriage that will elevate her family's standing. But en route to the imperial city of Inako, Mariko...

Hohenheim finally gets his chance to stop the mysterious homunculus "father" who rules over Central City. Will Hohenheim's surprise be enough to defeat the most powerful homunculus of them all? And when King Bradley makes a triumphant return, will the battle turn in the military's favor?

"In an alchemical ritual gone wrong, Edward Elric lost his arm and his leg, and his brother Alphonse became nothing but a soul in a suit of armor. Equipped with mechanical 'auto-mail' limbs, Edward becomes a state alchemist, seeking the one thing that can restore his and his brother's bodies...the legendary Philosopher's Stone.A diabolical trap is set for President Bradley... If he is assassinated, a power vacuum will open that Mustang and his allies...

As Greed and King Bradley continue their battle, the mysterious homunculus "father" makes his move under Central City. In order to achieve his objectives, he will need to force Mustang to make an unthinkable choice. Meanwhile, Alphonse has the chance to regain his own body, but the sacrifice to do so may be too much.

Fifteen-year-old twins Sophie and Josh Newman continue their magical training in Paris with Nicholas Flamel, Scatty, and the Comte de Sant Germaine, pursued by Doctor Dee and the immortal Niccolo Machiavelli.

Josh has chosen to side neither with his twin sister Sophie nor Nicholas Flamel, but rather to fight alongside Dr. John Dee and Virginia Dare, while the immortal Machiavelli and Billy the Kid plan to set loose the monsters of Alcatraz on San Francisco.