The city of Boston is shocked by a series of shocking crimes in which wealthy men are forced to watch as their wives are brutalized, and Detective Jane Rizzoli believes the culprit is a man who is being influenced by a serial killer that has recently been arrested, but when the killer escapes from prison, Jane finds herself a target.

When Justin and Libby Denbe, along with their beautiful 15-year-old daughter, disappear, investigator Tessa Leone must race against time to expose the Denbes' darkest secrets to discover who would want to kidnap such a perfect little family and just how far they are willing to go.

Medical examiner Maura Isles and Boston homicide detective Jane Rizzoli investigate when a murderer begins placing his victims in the Crispin Museum and a young archaeologist goes missing.

Anne Fitzgerald, a former nun turned private investigator, is hired by the Archdiocese of Boston to investigate two claims of immaculate conception in Boston and Ireland, and quickly comes to realize that both young women, and possibly the entire human race, are in grave danger.

Boston private investigator Spenser takes it personally when he tells his client, FBI agent Dennis Doherty, that his wife, Jordan, is having an affair, only to have the couple murdered, and he sets out to bring Jordan's lover, Perry Alderson, head of a group that helps sponsor terrorists, to justice.

"Lily hasn't always had it easy, but that's never stopped her from working hard for the life she wants. She's come a long way from the small town in Maine where she grew up--she graduated from college, moved to Boston, and started her own business. So when she feels a spark with a gorgeous neurosurgeon named Ryle Kincaid, everything in Lily's life suddenly seems almost too good to be true ... But Ryle's complete aversion to relationships is disturbing....