When a twist of fate makes Jamie Sullivan his date at the homecoming dance, Landon Carter never dreamed they would fall in love, but as he comes to realize his true feelings for Jamie, he learns of a terrible secret that will take his love away from him forever.

Seventeen-year-old Greg has managed to become part of every social group at his Pittsburgh high school without having any friends, but his life changes when his mother forces him to befriend Rachel, a girl he once knew in Hebrew school who has leukemia.