Brilliant Egyptologist Dr. Julius Kane accidentally unleashes the Egyptian god Set, who banishes the doctor to oblivion and forces his two children to embark on a dangerous journey, bringing them closer to the truth about their family and its links to a secret order that has existed since the time of the pharaohs.

Carter and Sadie, offspring of the brilliant Egyptologist Dr. Julius Kane, embark on a worldwide search for the Book of Ra, but the House of Life and the gods of chaos are determined to stop them.

When Apophis, the chaos snake, threatens to plunge the world into eternal darkness, siblings Carter and Sade Kane plan to use an ancient spell to destroy the snake, but first must rely on the murderous ghost of a powerful magician.

Granted the gift of immortality by the gods, King Tut, living as an eighth-grader in Washington, D.C., has been stuck in middle school for ages and to make things worse, evil General Horemheb, in league with the Cult of Set, is seeking revenge for his 3,000-year imprisonment at Tut's hands.